The fourth season of the American television drama series Masters of Sex is scheduled to premiere on September 11, 2016, and consist of 12 episodes. Showtime will broadcast the fourth season on Sundays at 10:00 pm (ET) in the United States.

The series was developed for television by Michelle Ashford and is based on the biography Masters of Sex: The Life and Times of William Masters and Virginia Johnson, the Couple Who Taught America How to Love by Thomas Maier. Masters of Sex tells the story of Dr. William Masters (Michael Sheen) and Virginia Johnson (Lizzy Caplan), two pioneering researchers of human sexuality at Washington University in St. Louis, Missouri. The fourth season takes place in 1968 and into the 1970s.