Miss Monochrome: The Animation (ミス・モノクローム -The Animation-) was produced by Liden Films and aired on TV Tokyo between October 1 and December 24, 2013. Additionally, it was released by Niconico Channel, Bandai Channel, AT-X in Japan and by Crunchyroll for viewers outside of Japan and Taiwan. An English dub of the series was released on Crunchyroll on July 21, 2015. The ending theme is "Pokerface" (ポーカーフェイス, Pōkāfeisu) by Miss Monochrome (Yui Horie).

A second season began airing from July 3, 2015. The opening and ending themes respectively are "Black or White?" and "Step by Step", both performed by Miss Monochrome. A third season will begin airing from October 2, 2015.