The guys prepare their house for their first time doing LSD, but Anders is called away on a business trip at a swanky hotel to meet a client named "The Barracuda", played by Kiersten Warren. Blake and Adam find their way into Anders' room and get everyone in the group to drop acid, including Alice and Anders' client.
The three are getting excited for a pizza-eating contest. They cannot get in contact with their drug dealer, Karl, and Adam suggests they go to a tattoo parlor to search for a new drug dealer. After Adam gets his belly button pierced, a tattoo artist, Lisa (Rumer Willis) becomes their new dealer. Karl comes over later and becomes offended when he learns they bought weed from someone else. The guys spend more time with Lisa and even get to meet Lori Beth Denberg (played by herself). Trouble arises when Lisa brings the guys their bill. They get threatened by Lisa's boss Cortez, who turns out to be Karl. He is upset and threatens to give up drug dealing and go to college. The gang wins free pizza for life at the pizza-eating contest and gives the prize to Karl to make up for everything.
Ders, Adam and Blake forget that TelAmeriCorp changed offices, and they arrive to work late after trashing the old office. At the new office, they cannot find a parking space and complain to Alice that there is no need for two handicap spaces. Adam suggests they bring his disabled cousin, Devin, to come work with them so they can use his handicap parking pass. Though he is reluctant, Devin's mother forces him to take the job. At work, he eats Montez's yogurt and hits it off with Jillian. Devin saves Anders from getting hit by a truck.
The three roommates try to get ready for a summer party. Blake unclogs the drain in the pool and discovers a dead dog, which he claims is "Rancho Chupacabraj" and carries it around in a backpack. They go to Montez's garage sale for pool toys and wind up purchasing a hovercraft, which they soon learn does not work. They take Montez to small-claims court over the matter.
The three discover one of their coworkers, "Homegirl", has passed away at work. They try to get out of work for the day by claiming how "butt-hurt" they are, but are unsuccessful. Instead, Alice agrees they may hold a service for "Homegirl". Meanwhile, Anders is trying to entertain his female pen pal and her friend. The memorial service turns into a battle between Adam, Anders and Blake in attempts to woo the girls.
Anders is worried about his father visiting because he has been lying about his life to him. He attempts to cover it up by squatting in a nicer home down the street. At the same time, Adam and Blake have started to make their own jerky by cutting up an entire cow in the house. They are upset with Anders because he is upset with them. Anders' father Thor is played by William Atherton.
Adam gets inspired to join a religious strong-man group called "The Lord's Force." The three meet two of the strong men and convince them to go out for a drink with them. Trouble arises, however, when the men's manager (Tim Heidecker) catches them kissing and kicks them out of the group. The three feel responsible and invite the two to stay with them. They try to start a rival strong-man group called "The Gaylords' Force".
The gang leaves a series of angry voicemails for Alice on her work phone. They realize their mistake and try to beat her to work to delete them, but soon find out they are still drunk. They continue drinking to avoid a hangover on their way to the office. Part of the episode spoofs the film Speed and even features the bus driver from the film as the bus driver in the episode.
When Montez suspects that his wife Colleen (Alex Borstein) is cheating on him, the guys help him find the culprit, until they found out that she and Montez made a deal.
The episode takes place in a flashback when the three met during college, with Blake and Adam as freshmen roommates and Anders as their resident advisor. Adam and Blake get Anders kicked off the swim team, which leads to their first bonding moments over beers. They decide to throw a pool party and Karl in a spoof scene similar to Good Will Hunting. After the party gets busted, the three get kicked off campus and search for jobs. They turn down offers from their future employer, Alice, at the TelAmeriCorp booth.
The guys are determined to be the funniest at the office roast, though no one else believes they are funny. The gang hatches up a clever plan, but then it goes way too far as Bill takes the whole office hostage. Montez becomes closer with Waymond and Jet Set.
After an evening of no sleep because of a movie marathon, Adam is having a tough time in the office while preparing for the "super moon" with Ders. Things get spooky when the guys discover a former employee (Robert Englund) may be haunting the office. The group finds a creepy painting of the former employee that keeps showing up throughout the office during renovations.
After letting the gang play with guns in the office, Alice is reprimanded to the point that she decides to quit. She is quickly replaced with Travis (Daniel Stern), a crazy boss who forces the gang to take their penises out to prove their manhood. The guys must come up with a plan to get Alice back after their new boss forces them to sit at separate desks.
After seeing Jillian's star running back cousin Billy play a game, the dudes become obsessed with betting on high-school sports. They approach a group of students who are the official bookies of the school and make bets on all kinds of sports, but lose all their money. The gang bets against Billy's team and tries to get him drunk the night before a game in order to make all their money back.
Alone on Valentine's Day, the guys turn to a webcam girl for romance. All three wind up falling in love with the girl. The guys then find out her IP address so they can find her and rescue her from her webcam life. The guys show up to the address and things get crazy.[
