An army captain is on a mission to track down and destroy a terrorist gang and deactivate the sleeper cells under its command.
       Jagdish (Vijay), an army captain, is back in Mumbai for a holiday to be with his parents and two sister. They want him to get married and finds a bride Nisha (Kajal Aggarwal) for him. After the usual bickerings the couple fall in love. Meanwhile Jagadish an intelligence officer in the military, has a mission to crack down on terrorist sleeper cells in Mumbai. How Jagadish moving around as an ordinary peron using his brain and brawn in the correct measure, tracks down the terrorist in his own unique way forms the rest of this escapist entertainer.

Thuppakki is basically about Jagdish (Vijay), an army captain, who returns to Mumbai for a 40 days’ vacation. He has a loving family, comprising two sisters and his parents, who wish to get him married to an appropriate girl. After some cat and mouse episodes with Nisha (Kajal), the arranged bride, Jagdish’s personal life is set with her.
　　On the other hand, he has a greater task at hand as he has to eradicate sleeper cells that are out to bomb and terrorize Mumbai across 12 prominent localities. These sleeper cells are controlled by one main man (Vidyut Jamwal) who is also later drawn into the city thanks to Jagdish’s proactive and intelligent moves in eliminating the cells through a secretive mission which he carries out with the help of his colleagues, who assemble for a marriage.
　　Later it becomes a straight game of one-upmanship between the main man and Jagdish. How Jagdish vanquishes him and how Jagdish manages to save the lives of people who are lured into this mean battle, is the remaining part of this extravagant and stylish entertainer which rides on the ever-dependable Vijay.
　　Vijay plays the role of an encounter specialist while Kajal Agarwal plays the character, Nisha, an iron-willed girl. She plays a very important role in Thuppakki. She will be seen in the role of a boxer in the film. However, the actress will also be seen in glamorous avatars. Akshara Gowda is to play the second female lead. Bollywood actor Vidyut Jamwal is donning the negative role.
　　Director AR Murugadoss makes a cameo appearance in the movie.
　　Camera is handled by award-winning cinematographer Santhosh Sivan and A. Sreekar Prasad has done editing. The soundtrack and background score are done by the talented music composer Harris Jayaraj. In Thuppakki, Vijay croons a song after a very long time.