A guy's life is turned around by an email, which includes the names of everyone he's had sex with and ever will have sex with. His situation gets wore when he encounter a femme fatale (Ryder) who targets men guilty of sex crime.
Just before he's to marry Fiona, Roderick Blank receives an anonymous e-mail with 101 names on it; Fiona's is the 29th, the firt 28 are women Rod has slept with, and the 30th turn out to be the stripper at his bachelor party. The notion that he will have sex with 70 more people sends Rod into crisis mode, especially after three odd men in an aseptic office confirm that a celestial machine has made an error. They suggest destroying the list, but Rod finds that easier said than done. Working his way through it conumes him, plus he realizes that death may await him after #101. Meanwhile, a femme fatale nicknamed Death Nell is putting men into a coma. Are they fated to meet?