From New York city girl Zoe Hart ( Rachel Bilson) are looking forward to their future, at the top of her class honors graduate from medical school, will follow in his father's footsteps as a cardiothoracic surgeon. But when Zoe's dream dies, she is forced to accept a queer Dr. Harley Wilkes's invitation, he started to work in small clinics. Away from the hustle and bustle of the city, Zoe alone came to the south coast town of Alabama Blue Bell town. Let Zoe surprise, Harley has passed away, but the clinic half ownership to bequeath to her. Zoe for the southern hospitality touched, but is this really true? No, Zoe soon found the flying wealth is a hot potato. In the town the other doctor Brick Breeland on Zoe disgust. Especially when he learned that he must and the unknown outsiders share clinic ownership, is a nest of a belly fire. The daughter of Brick Lemon ( Jaime King) is a typical southern belle, exudes a kind of sweet breath. But when she met with Zoe, both immediately become irreconcilable enemies.